Albuquerque Ricardo L C, Miguel Márcia C C, Costa Antonio L L, Souza Lélia B
Dentistry School, Tiradentes University, Aracaju, Sergipe, Brazil, and Laboratory of Oral Pathology, Dentistry School, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Int J Exp Pathol. 2003 Dec;84(6):259-65. doi: 10.1111/j.0959-9673.2004.00361.x.
An immunohistochemical analysis of 32 cases of oral squamous cell carcinoma (eight in the inferior lip, eight in the lateral angle of the tongue, eight in the palate and eight in the mouth floor) was performed to evaluate the expression pattern of c-erbB-2 protein and S-100-positive cells in the lesions. The immunohistochemical expression was correlated with the tumour anatomical site and histological grading of malignancy. A higher frequency of c-erbB-2-positive cases was found in the tongue, even though no correlation could be detected between the protein expression and the tumour histological grading. With respect to the S-100-positive cells, it was observed that a quantitative decrease was present in the cases classified as high-grade tumours when compared to the low ones (P = 0.0007). Thus, c-erbB-2 immunohistochemical expression is correlated with anatomical localization, and the expression of the S-100 Langerhans' cell markers is decreased significantly in high-grade carcinomas.
对32例口腔鳞状细胞癌（下唇8例、舌外侧缘8例、腭部8例、口底8例）进行免疫组化分析，以评估病变中c-erbB-2蛋白和S-100阳性细胞的表达模式。免疫组化表达与肿瘤的解剖部位及恶性组织学分级相关。尽管未检测到蛋白表达与肿瘤组织学分级之间的相关性，但在舌部发现c-erbB-2阳性病例的频率更高。关于S-100阳性细胞，观察到与低级别肿瘤相比，高级别肿瘤病例中S-100阳性细胞数量减少（P = 0.0007）。因此，c-erbB-2免疫组化表达与解剖定位相关，且高级别癌中S-100朗格汉斯细胞标志物的表达显著降低。
