Walsh T J, Groll A, Hiemenz J, Fleming R, Roilides E, Anaissie E
Immunocompromised Host Section, Pediatric Oncology Branch, The National Cancer Institute, Bethesda, MD 20892-1928, USA.
Clin Microbiol Infect. 2004 Mar;10 Suppl 1:48-66. doi: 10.1111/j.1470-9465.2004.00839.x.
The emergence of less common but medically important fungal pathogens contributes to the rate of morbidity and mortality, especially in the increasingly expanding population of immunocompromised patients. These pathogens include septate filamentous fungi (e.g., Fusarium spp., Scedosporium spp., Trichoderma spp.), nonseptate Zygomycetes, the endemic dimorphic pathogen Penicillium marneffei, and non-Cryptococcus, non-Candida pathogenic yeast (e.g., Trichosporon spp.). The medical community is thus called upon to acquire an understanding of the microbiology, epidemiology and pathogenesis of these previously uncommon pathogens in order to become familiar with the options for prevention and treatment.
一些不太常见但具有医学重要性的真菌病原体的出现,导致了发病率和死亡率,尤其是在日益增多的免疫功能低下患者群体中。这些病原体包括有隔丝状真菌(如镰刀菌属、赛多孢菌属、木霉属)、无隔接合菌、地方性双相病原体马尔尼菲青霉,以及非隐球菌、非念珠菌致病性酵母(如毛孢子菌属)。因此,医学界需要了解这些以前不常见病原体的微生物学、流行病学和发病机制,以便熟悉预防和治疗方案。