Sbracia Marco, Scarpellini Fabio, Poverini Roberto, Alò Piero Lvigi, Rossi Gabriele, Di Tondo Ugo
Center of Endocrinology and Reproductive Medicine, Rome, Italy.
Am J Reprod Immunol. 2004 Feb;51(2):112-6. doi: 10.1046/j.8755-8920.2003.00127.x.
Recent evidence of growth hormone (GH) receptor expression in rat endometrium and human myometrium have focused our attention on the role of the GH in endometrial development. We tested the expression of GH in the human endometrium throughout the menstrual cycle and during pregnancy.
Immunohistochemical study was performed on endometrial specimens of fertile women in different periods of the menstrual cycle and in decidua of pregnant women.
Glandular cells of the human endometrium were positive for GH in the mid and late luteal phase. Furthermore, the glandular cells of decidua showed intense staining for GH, while the stromal cells were negative. No immunostaining was expressed in the proliferative or early luteal phase. The intensity levels of staining for GH in decidual specimens were significantly higher than in glandular cells of secretory endometrium specimens (P < 0.01).
The glandular cells of the human endometrium express GH from the late luteal phase throughout pregnancy in the decidual tissue. We suppose that GH plays an important role in blastocyst implantation.
近期有证据表明生长激素（GH）受体在大鼠子宫内膜和人类子宫肌层中表达，这使我们将注意力集中在生长激素在子宫内膜发育中的作用上。我们检测了整个月经周期及孕期人子宫内膜中生长激素的表达情况。
对处于月经周期不同阶段的育龄妇女的子宫内膜标本以及孕妇的蜕膜进行免疫组织化学研究。
人子宫内膜的腺细胞在黄体中期和后期呈生长激素阳性。此外，蜕膜的腺细胞生长激素染色强烈，而基质细胞呈阴性。增殖期或黄体早期未出现免疫染色。蜕膜标本中生长激素的染色强度水平显著高于分泌期子宫内膜标本的腺细胞（P < 0.01）。
人子宫内膜的腺细胞在整个孕期从黄体后期开始在蜕膜组织中表达生长激素。我们推测生长激素在胚泡着床中起重要作用。
