Horie K, Takakura K, Imai K, Liao S, Mori T
Department of Gynaecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
Hum Reprod. 1992 Nov;7(10):1461-6. doi: 10.1093/oxfordjournals.humrep.a137595.
The immunohistochemical localization of the androgen receptor in the human endometrium at various stages of the menstrual cycle and post-menopausal period, in decidua and placenta of early pregnancy, and in several pathological conditions of the endometrium has been investigated. At any phase of the menstrual cycle, both endometrial glandular cells and endometrial stromal cells showed positive nuclear staining. Endometrial stromal cells of the functional layer showed stronger staining than those of the basal layer, but endometrial glandular cells of both layers showed the same staining intensity. There was little staining in myometrium. Even after menopause, endometrial glandular and stromal cells showed the same staining pattern as the basal layer of pre-menopausal endometrium and the staining intensity of endometrial stromal cells was weak. In decidua and placenta of early pregnancy, decidual and trophoblastic cells showed positive staining and there was no staining in the stromal cells of placenta. The expression of the androgen receptor was also detected in adenomyosis, endometriosis and endometrial carcinoma. Although the proliferation and differentiation of endometrium are mediated mainly by oestrogen and progesterone receptors, the androgen receptor may play some role in modulating these changes. These results suggest that it may be involved in both physiological and pathological changes of the endometrium.
已对雄激素受体在月经周期各阶段及绝经后期的人子宫内膜、早孕蜕膜和胎盘以及子宫内膜几种病理状况中的免疫组化定位进行了研究。在月经周期的任何阶段，子宫内膜腺细胞和子宫内膜基质细胞均显示细胞核染色阳性。功能层的子宫内膜基质细胞染色比基底层的更强，但两层的子宫内膜腺细胞染色强度相同。肌层几乎无染色。即使在绝经后，子宫内膜腺细胞和基质细胞的染色模式与绝经前子宫内膜基底层相同，且子宫内膜基质细胞的染色强度较弱。在早孕蜕膜和胎盘中，蜕膜细胞和滋养层细胞显示阳性染色，胎盘基质细胞无染色。在子宫腺肌病、子宫内膜异位症和子宫内膜癌中也检测到雄激素受体的表达。虽然子宫内膜的增殖和分化主要由雌激素和孕激素受体介导，但雄激素受体可能在调节这些变化中发挥一定作用。这些结果表明，它可能参与子宫内膜的生理和病理变化。
