Belsito Donald V
Division of Dermatology, University of Kansas Medical Center, Kansas City, KS, USA.
Am J Contact Dermat. 2003 Jun;14(2):95-6.
The diagnosis of allergic contact dermatitis of the feet is challenging because the constituents of shoes are not labeled. In addition, the materials and technologies used in the manufacturing of shoes are continuously evolving. Since the 1950s, rubber allergens have been the most common cause of shoe dermatitis. However, the causal allergens in rubber have changed. Instead of 2-mercaptobenzothiazole, dithiodimorpholine, an allergen that is not contained on standard patch-testing trays, now may be one of the more common rubber sensitizers in shoes. Other allergens not found on standard series that can account for shoe dermatitis include isophorone diisocyanate, dimethylaminoethyl ether, and mixed dialkyl thioureas. Therefore, physicians evaluating patients with allergic-appearing foot dermatitis need to test with allergens beyond those present on standard screening series.
足部过敏性接触性皮炎的诊断颇具挑战性，因为鞋子的成分并未标明。此外，制鞋所使用的材料和技术也在不断发展。自20世纪50年代以来，橡胶过敏原一直是鞋类皮炎最常见的病因。然而，橡胶中的致病过敏原已经发生了变化。现在，二硫代吗啉（一种标准斑贴试验盘中不含的过敏原）而非2-巯基苯并噻唑，可能是鞋类中更常见的橡胶致敏剂之一。标准系列中未发现但可导致鞋类皮炎的其他过敏原包括异佛尔酮二异氰酸酯、二甲基氨基乙醚和混合二烷基硫脲。因此，评估足部出现过敏性皮炎患者的医生需要使用标准筛查系列以外的过敏原进行检测。
