Goldberg Sara, Smith Gwenn S, Barnes Anna, Ma Yilong, Kramer Elisse, Robeson Kimberly, Kirshner Margaret, Pollock Bruce G, Eidelberg David
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, USA.
Neurobiol Aging. 2004 Feb;25(2):167-74. doi: 10.1016/s0197-4580(03)00088-5.
Age-related alterations in serotonin function may increase the vulnerability to psychiatric and neurodegenerative disorders in late life. The neuroendocrine and cerebral metabolic response to the acute administration of the selective serotonin reuptake inhibitor, citalopram (40mg, IV), was measured in 17 normal control subjects using positron emission tomography (PET) to evaluate changes in serotonin function with normal aging. The citalopram-induced change in cerebral metabolism was positively correlated with age in the right precuneus, right paracentral lobule, and left middle temporal gyrus and negatively correlated with age in the left anterior cingulate gyrus, right inferior and middle frontal gyri, right insula, and right inferior parietal lobule. The positive correlations in mainly posterior brain regions indicate that normal aging is associated with an increase in metabolism after citalopram administration, whereas the negative correlations in mainly anterior brain regions indicate that normal aging is associated with a greater decrease in metabolism. These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation.
血清素功能随年龄的变化可能会增加晚年患精神疾病和神经退行性疾病的易感性。在17名正常对照受试者中，使用正电子发射断层扫描（PET）测量了对选择性血清素再摄取抑制剂西酞普兰（40mg，静脉注射）急性给药的神经内分泌和脑代谢反应，以评估血清素功能随正常衰老的变化。西酞普兰引起的脑代谢变化在右侧楔前叶、右侧中央旁小叶和左侧颞中回与年龄呈正相关，而在左侧前扣带回、右侧额下回和额中回、右侧岛叶和右侧顶下小叶与年龄呈负相关。主要在大脑后部区域的正相关表明，正常衰老与服用西酞普兰后代谢增加有关，而主要在大脑前部区域的负相关表明，正常衰老与代谢更大程度的降低有关。这些结果表明，与血清素神经支配随年龄相关丧失继发的大脑后部区域相比，大脑前部区域存在不同的代偿过程。
