Smith Gwenn S, Ma Yilong, Dhawan Vijay, Gunduz Handan, Carbon Maren, Kirshner Maggie, Larson Jennifer, Chaly Thomas, Belakhleff Abdel, Kramer Elisse, Greenwald Blaine, Kane John M, Laghrissi-Thode Fouzia, Pollock Bruce G, Eidelber David
Department of Psychiatry Research, Hillside Hospital, Neuroscience Institute of the North Shore--Long Island Jewish Health System, Glen Oaks, New York 11004, USA.
Synapse. 2002 Aug;45(2):105-12. doi: 10.1002/syn.10088.
To develop a method to measure the dynamic response of the serotonin system in vivo, the effects of intravenously administered citalopram (the most selective of the serotonin reuptake inhibitors) on cerebral glucose metabolism were evaluated. Cerebral glucose metabolism was measured with positron emission tomography (PET) in 14 normal subjects scanned after administration of saline placebo and citalopram administered on 2 separate days. Citalopram administration resulted in a decrease in metabolism in the right anterior cingulate gyrus (BA 24/32), right superior (BA 9) and right middle frontal gyrus (BA 6), right parietal cortex (precuneus), right superior occipital gyrus, left thalamus, and right cerebellum. Increased metabolism was observed in the left superior temporal gyrus and left occipital cortex. Alterations in metabolism by acute citalopram administration involved the heteromodal association cortices that also show metabolic alterations in patients with geriatric depression and overlap with the regions affected by antidepressant treatment. Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression.
为开发一种在体内测量血清素系统动态反应的方法，评估了静脉注射西酞普兰（最具选择性的血清素再摄取抑制剂）对脑葡萄糖代谢的影响。在14名正常受试者中，于生理盐水安慰剂给药后以及在两个不同日期分别给予西酞普兰后，使用正电子发射断层扫描（PET）测量脑葡萄糖代谢。给予西酞普兰后，右侧前扣带回（BA 24/32）、右侧额上回（BA 9）和右侧额中回（BA 6）、右侧顶叶皮质（楔前叶）、右侧枕上回、左侧丘脑和右侧小脑的代谢降低。在左侧颞上回和左侧枕叶皮质观察到代谢增加。急性给予西酞普兰引起的代谢改变涉及异模态联合皮质，这些皮质在老年抑郁症患者中也显示出代谢改变，并且与抗抑郁治疗所影响的区域重叠。未来的研究将评估西酞普兰的急性代谢反应与老年抑郁症患者慢性治疗后的代谢反应之间的关系。
