Suzuki Koichi, Hata Shoji, Kawabata Yukiko, Sorimachi Hiroyuki
Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Diabetes. 2004 Feb;53 Suppl 1:S12-8. doi: 10.2337/diabetes.53.2007.s12.
Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential to understand its physiological functions, is discussed on the basis of recent X-ray structural analyses. Further, special features of the structure of calpain 10 that differ from those of typical micro - or m-calpain used in most studies are summarized together with discussion of the physiological function of calpain with respect to type 2 diabetes.
钙蛋白酶10基因的变异最近通过定位克隆被证明与2型糖尿病相关。从那时起，关于钙蛋白酶10与糖尿病和胰岛素介导信号传导相关性的研究就已经展开。在这篇综述中，基于最近的X射线结构分析，讨论了钙离子对钙蛋白酶的激活机制，这对于理解其生理功能至关重要。此外，总结了钙蛋白酶10结构与大多数研究中使用的典型微钙蛋白酶或中钙蛋白酶结构不同的特点，并讨论了钙蛋白酶在2型糖尿病方面的生理功能。
