Trajkovski Mirko, Mziaut Hassan, Schwarz Peter E, Solimena Michele
Experimental Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.
Endocrinol Metab Clin North Am. 2006 Jun;35(2):357-69, x. doi: 10.1016/j.ecl.2006.02.008.
Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.
2型糖尿病是一种具有流行趋势的复杂多基因代谢紊乱疾病。本综述简要概述了主要影响胰腺β细胞的2型糖尿病易感基因，重点介绍了它们的功能和最相关的多态性。我们重点关注钙蛋白酶10，它是迄今为止通过定位克隆方法在糖尿病患者中鉴定出的唯一易感基因。
