Hoshi Eiji, Tanji Jun
Department of Physiology, Tohoku University School of Medicine, Seiryo-cho 2-1, Aoba-ku, Sendai 980-8575, Japan.
J Neurophysiol. 2004 Jun;91(6):2707-22. doi: 10.1152/jn.00904.2003. Epub 2004 Jan 28.
We compared how neurons in the dorsal and ventral regions of the dorsolateral prefrontal cortex (dl-PFC) participate in processing 2 sets of sensory signals, given at intervals, to generate plans for future actions. For the first set of visual signals, neurons in the ventral region of dl-PFC responded preferentially to the visuospatial properties of the signal, whereas neurons in the dorsal region of dl-PFC were involved primarily in retrieving information from the signal, such as the location of the target or which arm to use. For the second set of visual signals, most ventral dl-PFC neurons reflected either the sensory properties of the signals or the information retrieved from each signal. By contrast, dorsal neurons were involved more in integrating information about the target location and which arm to use to reach the target, thereby generating information that could be used to plan future actions. Thus sensorimotor transformations in the dorsolateral PFC appear to be time-variant and region-selective.
我们比较了背外侧前额叶皮层（dl-PFC）背侧和腹侧区域的神经元如何参与处理两组间隔给出的感觉信号，以生成未来行动的计划。对于第一组视觉信号，dl-PFC腹侧区域的神经元优先对信号的视觉空间特性做出反应，而dl-PFC背侧区域的神经元主要参与从信号中检索信息，例如目标的位置或使用哪只手臂。对于第二组视觉信号，大多数腹侧dl-PFC神经元反映了信号的感觉特性或从每个信号中检索到的信息。相比之下，背侧神经元更多地参与整合关于目标位置和使用哪只手臂到达目标的信息，从而生成可用于规划未来行动的信息。因此，背外侧前额叶皮层中的感觉运动转换似乎是随时间变化且具有区域选择性的。
