Averna M R, Barbagallo C M, Di Paola G, Labisi M, Pinna G, Marino G, Dimita U, Notarbartolo A
Cattedra di Patologia Medica, Università degli Studi di Palermo.
Minerva Pediatr. 1992 Sep;44(9):395-9.
The aim of the present study was to evaluate, in a large series of term newborns, the prevalence of hypercholesterolemia in cord blood, using as parameters, levels of plasma cholesterol, LDL-cholesterol and apo B higher than mean + 2 standard deviations, alone or in association. Data reported here represent the results of a transversal study. 1275 term newborns were studied. In everybody, in cord blood samples, at birth, cholesterol, triglycerides, HDL-cholesterol, apoprotein B and LDL-cholesterol have been assayed. In 3.13% of them (40 subjects), cholesterol levels > mean + 2 standard deviations were present. Moreover, only 6 subjects (0.47%) showed all three parameter levels higher than mean + 2 standard deviations, and 4 subjects (0.31%), in spite of normal cholesterol levels, presented high LDL-cholesterol and apo B levels. Integrated utilization of these parameters in the neonatal screening of familial hypercholesterolemia will have to be confirmed by follow-up studies.
本研究的目的是在大量足月儿中，以血浆胆固醇、低密度脂蛋白胆固醇和载脂蛋白B水平高于均值加2个标准差为参数，单独或联合使用，评估脐血中高胆固醇血症的患病率。此处报告的数据代表一项横断面研究的结果。对1275名足月儿进行了研究。对每个人出生时的脐血样本进行了胆固醇、甘油三酯、高密度脂蛋白胆固醇、载脂蛋白B和低密度脂蛋白胆固醇的检测。其中3.13%（40名受试者）的胆固醇水平>均值加2个标准差。此外，只有6名受试者（0.47%）的所有三个参数水平均高于均值加2个标准差，4名受试者（0.31%）尽管胆固醇水平正常，但低密度脂蛋白胆固醇和载脂蛋白B水平较高。在家族性高胆固醇血症的新生儿筛查中综合利用这些参数有待后续研究证实。
