Pac-Kozuchowska Elzbieta
Department of Paediatric Propedeutics, Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):25-32.
The period of foetal life as the first stage in the individual development is very important for every man. This is a period in which the greatest dynamics of developmental changes and particularly great susceptibility to the influence of negative factors are observed. The exponent of the correct prenatal life of the foetus is the birth weight of a newborn, which defines the degree of biological maturity of the child and its ability to live in the course of the subsequent stages of individual life. Therefore, the aim of the present study was to check the influence of foetal life on some of the parameters of lipids metabolism in the cord blood serum in healthy newborns as well as the evaluation of the concentration of lipids, lipoproteins and apolipoproteins with relation to the birth weight and also the gestational age of the studied newborns. The study was carried out on 137 healthy newborns (63 boys and 74 girls). In all of the studied newborns concentration of triglycerides, total cholesterol, LDL-cholesterol, VLDL-cholesterol and HDL-cholesterol as well as of apolipoproteins (apo-Al, apo-B) in the cord blood serum sampled soon after birth was studied. In the cord blood serum of the LBW newborns higher values of triglycerides, total cholesterol, cholesterol in fraction VLDL and apolipoprotein B were confirmed as well as the tendency towards lower values of HDL-cholesterol, which is an unfavourable phenomenon from the point of the risk of arteriosclerosis. No statistically significant differences in the level of lipids, lipoproteins and apolipoproteins in cord blood serum of the studied newborns depending on their gestational age were confirmed. The results may suggest that the risk factors of cardiovascular disease may to great extent depend on the intrauterine development and low birth weight.
胎儿期作为个体发育的第一阶段，对每个人都非常重要。这是一个发育变化动态最大、对负面因素影响特别敏感的时期。胎儿正确的产前生活指标是新生儿的出生体重，它决定了儿童的生物成熟程度及其在个体生命后续阶段的生存能力。因此，本研究的目的是检查胎儿期对健康新生儿脐带血血清中某些脂质代谢参数的影响，以及评估脂质、脂蛋白和载脂蛋白的浓度与研究新生儿的出生体重和胎龄的关系。该研究对137名健康新生儿（63名男孩和74名女孩）进行。对所有研究的新生儿，在出生后不久采集的脐带血血清中甘油三酯、总胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇和高密度脂蛋白胆固醇以及载脂蛋白（载脂蛋白A1、载脂蛋白B）的浓度进行了研究。在低出生体重新生儿的脐带血血清中，甘油三酯、总胆固醇、极低密度脂蛋白部分的胆固醇和载脂蛋白B的值较高，而高密度脂蛋白胆固醇的值有降低的趋势，从动脉粥样硬化风险的角度来看，这是一个不利现象。未证实所研究新生儿的脐带血血清中脂质、脂蛋白和载脂蛋白水平因胎龄不同而存在统计学显著差异。结果可能表明，心血管疾病的危险因素在很大程度上可能取决于宫内发育和低出生体重。
