淋巴细胞发育与功能的年龄相关变化。
Age-related changes in lymphocyte development and function.
作者信息
Linton Phyllis Jean, Dorshkind Kenneth
机构信息
Sidney Kimmel Cancer Center, San Diego, California 92121, USA.
出版信息
Nat Immunol. 2004 Feb;5(2):133-9. doi: 10.1038/ni1033.
DOI:10.1038/ni1033
PMID:14749784
Abstract
The effects of aging on the immune system are widespread and extend from hematopoietic stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes in secondary lymphoid organs. These changes combine to result in a diminution of immune responsiveness in the elderly. This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research.
摘要
衰老对免疫系统的影响广泛存在，从骨髓和胸腺中的造血干细胞及淋巴祖细胞，延伸至次级淋巴器官中的成熟淋巴细胞。这些变化共同导致老年人免疫反应性降低。本综述旨在概述淋巴细胞发育和功能方面与年龄相关的变化，并讨论衰老研究领域当前存在的争议。
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