Van Lith J M, Pratt J J, Beekhuis J R, Mantingh A
Department of Obstetrics and Gynaecology, University Hospital Groningen, The Netherlands.
Prenat Diagn. 1992 Oct;12(10):801-6. doi: 10.1002/pd.1970121005.
We measured immunoreactive inhibin in the maternal serum of 80 pregnancies with a chromosomally normal fetus and ten Down's syndrome pregnancies in the second trimester. The inhibin level in all Down's syndrome pregnancies was above the normal median; the multiple of the normal median (MoM) was 1.9. We found a statistically significant difference between the levels of inhibin in unaffected and affected pregnancies (Kolmogorov-Smirnov test: p < 0.002). Using an arbitrarily chosen cut-off of 2.4 MoM, 40 per cent of Down's syndrome and 5 per cent of the normal pregnancies were found. We conclude that immunoreactive inhibin may be useful as a marker for fetal Down's syndrome.
我们检测了孕中期80例胎儿染色体正常的孕妇及10例唐氏综合征孕妇母血清中的免疫反应性抑制素。所有唐氏综合征孕妇的抑制素水平均高于正常中位数；正常中位数倍数（MoM）为1.9。我们发现未受影响和受影响的孕妇之间抑制素水平存在统计学显著差异（柯尔莫哥洛夫-斯米尔诺夫检验：p < 0.002）。采用任意选定的2.4 MoM临界值，发现40%的唐氏综合征孕妇和5%的正常孕妇符合该标准。我们得出结论，免疫反应性抑制素可能作为胎儿唐氏综合征的一个标志物。
