钠负荷（3%氯化钠）对大鼠肝微粒体中花生四烯酸生物合成的影响。

Effect of sodium loading (3% NaCl) on arachidonic acid biosynthesis in rat liver microsomes.

作者信息

Narce M, Mimouni V, Poisson J P

机构信息

Unité de Recherche de Nutrition Cellulaire et Métabolique, Université de Bourgogne, Dijon, France.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1992 Nov;47(3):193-7. doi: 10.1016/0952-3278(92)90238-e.

DOI:10.1016/0952-3278(92)90238-e

PMID:1475274

Abstract

Sodium loading increases arachidonic acid (AA) metabolism by way of the prostaglandins(PGs) from series 2. Its effect on AA biosynthesis remains unknown. The purpose of the present study was to investigate the influence of sodium loading on the fatty acid composition of liver and liver microsomes, and the liver microsomal delta-6 and delta-5 desaturations of linoleic acid (LA) into AA. We found a decrease of LA and dihomo-gamma-linolenic acid (DGLA) levels in liver total lipids of Wistar rats receiving hypernatriuretic drinking water (NaCl 3%) for 60 days. At the same time AA increased. DGLA decreased and AA increased in liver microsomal total lipids. 1(14) C-LA delta-6 desaturase and 2(14) C-DGLA delta-5 desaturase activities increased in liver microsomes. These results show that, in addition to its influence on the regulation of glomerular filtration, sodium loading is involved in the regulation of liver AA biosynthesis.

摘要

钠负荷通过2系列前列腺素（PGs）增加花生四烯酸（AA）代谢。其对AA生物合成的影响尚不清楚。本研究的目的是探讨钠负荷对肝脏和肝脏微粒体脂肪酸组成以及肝脏微粒体中亚油酸（LA）向AA的δ-6和δ-5去饱和作用的影响。我们发现，饮用高钠利尿饮用水（3%NaCl）60天的Wistar大鼠肝脏总脂质中LA和二高-γ-亚麻酸（DGLA）水平降低。同时，AA增加。肝脏微粒体总脂质中DGLA降低而AA增加。肝脏微粒体中1(14)C-LA δ-6去饱和酶和2(14)C-DGLA δ-5去饱和酶活性增加。这些结果表明，钠负荷除了影响肾小球滤过调节外，还参与肝脏AA生物合成的调节。