Ghaly E S, Hernández J I, Malavé A, Marti A
School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, San Juan 00936.
P R Health Sci J. 1992 Dec;11(3):159-62.
In this study ethylcellulose was evaluated as a carrier for preparation of prolonged release acetaminophen tablets. Solid dispersions containing three levels of ethylcellulose and acetaminophen (1:3; 1:1; 3:1) were prepared by the solvent method. Also physical mixtures at the same level of ethylcellulose and acetaminophen were prepared. Systems composed of solid dispersion or physical mixture containing the equivalent weight of 50 mg acetaminophen, Emcompress as diluent and 1% magnesium stearate as lubricant were compressed into tablets and tested for dissolution. The dissolution data showed that the drug release decreased as the level of ethylcellulose increased in the solid dispersion formulations. The drug release from tablets prepared with solid dispersion followed the diffusion controlled model for inert porous matrix, while the drug release from tablets prepared with physical mixture followed the first-order kinetic model.
在本研究中，对乙基纤维素作为制备对乙酰氨基酚缓释片的载体进行了评估。采用溶剂法制备了含有三种比例乙基纤维素和对乙酰氨基酚（1:3；1:1；3:1）的固体分散体。还制备了相同比例乙基纤维素和对乙酰氨基酚的物理混合物。将由含有相当于50mg对乙酰氨基酚的固体分散体或物理混合物、作为稀释剂的Emcompress和作为润滑剂的1%硬脂酸镁组成的体系压制成片剂，并进行溶出度测试。溶出度数据表明，在固体分散体制剂中，随着乙基纤维素比例的增加，药物释放减少。固体分散体制备的片剂的药物释放遵循惰性多孔基质的扩散控制模型，而物理混合物制备的片剂的药物释放遵循一级动力学模型。
