Ghaly E S, Hernández J I, Malavé A, Marti A
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
P R Health Sci J. 1993 Dec;12(4):273-6.
In this study, ethylcellulose was evaluated as a carrier for the preparation of sustained release of acetaminophen via solid dispersion technique. Physical mixture at the same level of acetaminophen and ethylcellulose was prepared. Differential scanning calorimetry and scanning electron microscope were used to characterize the physical properties of the various systems and to determine if there is possible interaction between acetaminophen and ethylcellulose.
在本研究中，对乙基纤维素作为载体通过固体分散技术制备对乙酰氨基酚缓释制剂进行了评估。制备了对乙酰氨基酚和乙基纤维素处于相同水平的物理混合物。采用差示扫描量热法和扫描电子显微镜对各体系的物理性质进行表征，并确定对乙酰氨基酚与乙基纤维素之间是否可能存在相互作用。
