Sirivichayakul C, Pojjaroen-Anant C, Wisetsing P, Praevanit R, Chanthavanich P, Limkittikul K
Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand.
Ann Trop Med Parasitol. 2003 Dec;97(8):847-53. doi: 10.1179/000349803225002480.
A randomized clinical trial was carried out to study the relationship between the duration of albendazole therapy, at 400 mg/day, and its effectiveness in the treatment of Trichuris trichiura infection. The 168 patients were treated for three (N=56), five (N=56) or seven (N=56) consecutive days. Compared with both of the shorter regimens, treatment for 7 days resulted in a significantly higher cure 'rate' and significantly greater reductions in the level of egg excretion. The advantage of using the longer (5- or 7-day) regimens was most apparent among the patients who had heavy infections (at least 1000 Trichuris eggs/g faeces) when treated. It is therefore suggested that albendazole be given for at least 3 days to those with light infections and for 5-7 days to patients with heavy infections.
进行了一项随机临床试验，以研究阿苯达唑400毫克/天的治疗疗程与其治疗鞭虫感染有效性之间的关系。168名患者连续治疗三天（N = 56）、五天（N = 56）或七天（N = 56）。与两种较短疗程相比，治疗7天导致治愈率显著更高，且虫卵排泄水平显著降低。在治疗时感染严重（至少1000个鞭虫卵/克粪便）的患者中，采用较长（5天或7天）疗程的优势最为明显。因此，建议对轻度感染患者给予阿苯达唑治疗至少3天，对重度感染患者给予5 - 7天治疗。
