[癌前病变和非黑素瘤皮肤癌中的预后分子因素]

[The prognostic molecular factors in precancerous lesions and nonmelanotic skin carcinoma].

作者信息

Mihailovici Maria Sultana, Teleman S, Ungureanu Carmen

机构信息

Facultatea de Medicină Disciplina de Morfopatologie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2003 Jul-Sep;107(3):494-501.

PMID:14756051

Abstract

The most common cutaneous carcinoma, which includes basal cell carcinoma (BCC) and squamous cell carcinomas (SCC), accounts for approximately 90% or more of all skin malignancies. Actinic keratosis, bowenoid type of actinic keratosis, Bowen's disease or SCC in situ have been considered precursors of skin SCC. Authors present the histopathological criteria of precursors of skin SCC, variants invasive SCC and BCC. Also, one discusses about the roles of immunohistochemical staining of gene products in evidence of molecular changes in cell that might occur according to the transformation from precancerous lesions to SCC.

摘要

最常见的皮肤癌，包括基底细胞癌（BCC）和鳞状细胞癌（SCC），约占所有皮肤恶性肿瘤的90%或更多。光化性角化病、鲍温样光化性角化病、鲍温病或原位鳞状细胞癌被认为是皮肤鳞状细胞癌的前驱病变。作者介绍了皮肤鳞状细胞癌前驱病变、侵袭性鳞状细胞癌变体和基底细胞癌的组织病理学标准。此外，还讨论了基因产物免疫组化染色在癌前病变向鳞状细胞癌转变过程中可能发生的细胞分子变化证据中的作用。