Pfeiffer A, Schmidt T, Vidon N, Pehl C, Kaess H
2nd Medical Dept., München-Bogenhausen Hospital, Germany.
Scand J Gastroenterol. 1992 Dec;27(12):1023-30. doi: 10.3109/00365529209028133.
Duodenal and jejunal absorption of a nutrient solution at two different caloric loads (1.32 and 3.96 kcal/min = 5.6 and 16.8 kJ/min) was compared in chronic alcoholics without malnutrition, liver cirrhosis, obvious small-bowel dysfunction, and exocrine pancreatic insufficiency and in an age-matched control group, by means of the intestinal perfusion technique. In chronic alcoholics duodenal net absorption of water (p < 0.025), sodium (p < 0.02), potassium (p < 0.005), total nitrogen (p < 0.02), carbohydrates (p < 0.05), and lipids (p < 0.05) was lower than in controls when both caloric loads were administered, but jejunal absorption rates were not decreased. Biliopancreatic secretion did not differ between alcoholics and controls. Higher serum protein leakage in alcoholics was indicated by an increased (p < 0.01) duodenal alpha 1-antitrypsin clearance under low caloric load infusion. It is concluded that the absorptive function of the duodenum is impaired in alcoholics, whereas the upper jejunum is not affected.
采用肠道灌注技术，对无营养不良、肝硬化、明显小肠功能障碍及外分泌性胰腺功能不全的慢性酒精中毒患者和年龄匹配的对照组，比较了两种不同热量负荷（1.32和3.96千卡/分钟 = 5.6和16.8千焦/分钟）下营养液在十二指肠和空肠的吸收情况。在慢性酒精中毒患者中，当给予两种热量负荷时，十二指肠对水（p < 0.025）、钠（p < 0.02）、钾（p < 0.005）、总氮（p < 0.02）、碳水化合物（p < 0.05）和脂质（p < 0.05）的净吸收低于对照组，但空肠吸收率未降低。酒精中毒患者和对照组之间的胆胰分泌无差异。在低热量负荷输注时，酒精中毒患者十二指肠α1-抗胰蛋白酶清除率增加（p < 0.01），提示血清蛋白漏出增加。结论是，酒精中毒患者十二指肠的吸收功能受损，而空肠上段未受影响。
