Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, Washington 98195-7260, USA.
Am J Gastroenterol. 2013 Feb;108(2):270-6. doi: 10.1038/ajg.2012.414. Epub 2013 Jan 8.
Heavy alcohol intake may exacerbate gastrointestinal (GI) symptoms in adults with irritable bowel syndrome (IBS); however, the role of alcohol in IBS is unclear. We investigated prospective associations between daily patterns of alcohol intake and next day's GI symptoms using daily diaries.
In an observational study of women aged 18-48 years with IBS and healthy controls, participants recorded daily GI symptoms, alcohol intake, caffeine intake, and cigarette smoking for ≈ 1 month. GI symptoms included abdominal pain, abdominal bloating, intestinal gas, diarrhea, constipation, nausea, stomach pain, heartburn, and indigestion. Binge drinking was defined as 4+ alcohol-containing drinks/day.
Patterns of alcohol intake did not differ between IBS patients and controls. Although patterns of drinking were associated with GI symptoms among women with IBS, this was not the case with the healthy controls. The strongest associations for IBS patients were between binge drinking and the next day's GI symptoms (e.g., diarrhea, P=0.006; nausea, P=0.01; stomach pain, P=0.009; and indigestion, P=0.004), whereas moderate and light drinking either were not associated or weakly associated with GI symptoms. Associations between alcohol intake and GI symptoms were stronger for women with IBS-diarrhea than for IBS-constipation or IBS-mixed. Effects of binge drinking on GI symptoms were strongest when comparing between individuals (rather than within individuals).
Our findings indicate that IBS symptoms differ according to the pattern of alcohol intake among IBS patients, suggesting that the pattern of drinking may in part explain the inconsistent findings between alcohol and IBS symptoms.
大量饮酒可能会加重成人肠易激综合征（IBS）患者的胃肠道（GI）症状；然而，酒精在 IBS 中的作用尚不清楚。我们通过每日日记来研究酒精摄入的日常模式与次日 GI 症状之间的前瞻性关联。
在一项针对 18-48 岁 IBS 女性患者和健康对照者的观察性研究中，参与者记录了大约 1 个月的每日 GI 症状、酒精摄入、咖啡因摄入和吸烟情况。GI 症状包括腹痛、腹胀、肠气、腹泻、便秘、恶心、胃痛、烧心和消化不良。 binge drinking 定义为每天饮用 4 份或以上含酒精饮料。
IBS 患者和对照组之间的饮酒模式没有差异。尽管饮酒模式与 IBS 女性的 GI 症状有关，但健康对照组并非如此。与 IBS 患者最相关的是 binge drinking 与次日 GI 症状之间的关联（例如，腹泻，P=0.006；恶心，P=0.01；胃痛，P=0.009；消化不良，P=0.004），而中度和轻度饮酒与 GI 症状无关或关联较弱。与 IBS-便秘或 IBS-混合患者相比，IBS-腹泻患者的饮酒和 GI 症状之间的关联更强。在个体之间（而不是个体内部）进行比较时， binge drinking 对 GI 症状的影响最强。
我们的研究结果表明，IBS 患者的症状根据饮酒模式而有所不同，这表明饮酒模式可能部分解释了酒精与 IBS 症状之间不一致的发现。
