Termorshuizen F, Hogewoning A A, Bouwes Bavinck J N, Goettsch W G, de Fijter J W, van Loveren H
Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Clin Transplant. 2003 Dec;17(6):522-7. doi: 10.1046/j.0902-0063.2003.00099.x.
Ultraviolet radiation (UVR) is an important risk factor for skin cancer in transplant recipients. In view of the potential suppressive effect of UVR on host resistance it was examined whether exposure to UVR was also associated with the occurrence of various skin infections.
In a cohort of renal transplant recipients (n = 137), lifetime exposure was assessed by means of a retrospective questionnaire on cumulative sunlight exposure. Diagnosed skin infections since renal transplantation were extracted from the patient's medical charts. Season of diagnosis was regarded as indicative of short-term exposure.
In comparison with winter a high rate of herpes simplex infections was found in spring [rate ratio (RR) = 4.09, 95% confidence interval (CI) 1.2-14.5], and high rates of herpes zoster infections (RR = 1.6, 95% CI: 0.8-3.5) and fungal/yeast infections in summer (RR = 2.1, 95% CI: 1.3-3.4). A higher lifetime exposure (RR = 2.31, 95% CI: 1.04-5.1) and a greater cumulative number of reported sunburns (RR = 2.3, 95% CI: 1.1-5.1) were independently associated with a higher risk of bacterial infections.
The seasonal association with the occurrence of clinical herpes infections indicates an effect of short-term UVR. Our data suggest that the number of sunburn episodes in the past is also relevant for the susceptibility to certain skin infections.
紫外线辐射（UVR）是移植受者患皮肤癌的一个重要危险因素。鉴于UVR对宿主抵抗力可能存在抑制作用，研究人员考察了UVR暴露是否也与各种皮肤感染的发生有关。
在一组肾移植受者（n = 137）中，通过一份关于累积阳光暴露的回顾性问卷评估终生暴露情况。从患者病历中提取肾移植后诊断出的皮肤感染情况。将诊断季节视为短期暴露的指标。
与冬季相比，春季单纯疱疹感染率较高[率比（RR）= 4.09，95%置信区间（CI）1.2 - 14.5]，夏季带状疱疹感染率较高（RR = 1.6，95% CI：0.8 - 3.5）以及真菌/酵母菌感染率较高（RR = 2.1，95% CI：1.3 - 3.4）。较高的终生暴露（RR = 2.31，95% CI：1.04 - 5.1）和报告的晒伤累积次数较多（RR = 2.3，95% CI：1.1 - 5.1）与细菌感染风险较高独立相关。
临床疱疹感染发生与季节的关联表明短期UVR有影响。我们的数据表明过去晒伤发作次数也与某些皮肤感染的易感性相关。
