Kisliakova N D, Luntovskaia V A, Polianichko M F, Volovel'skiĭ I Z
Vopr Onkol. 1978;24(1):86-9.
In cancer of the prostatic gland of stage II--III in males, 50--60 years, a reduced gonadial endocrine function is observed, that is manifested in a considerably reduced excretion of testosterone and estrogen. Because of the different rate of reduction in the testosterone and estrogen excretion in patients 50--69 years of age, one may observe the state of relative and in 70--80 years old patients--absolute hyperandrogenization of the organism, which is likely to be an unfavorable factor, taking into account the property of testosterone metabolites (dihydrotestosterone in particular) to enhance proliferative processes in the prostatic gland.
在50至60岁男性的II - III期前列腺癌患者中，观察到性腺内分泌功能减退，表现为睾酮和雌激素排泄量显著降低。由于50至69岁患者中睾酮和雌激素排泄量的降低速率不同，可能会观察到机体处于相对高雄激素化状态，而在70至80岁患者中则处于绝对高雄激素化状态。考虑到睾酮代谢产物（尤其是双氢睾酮）具有增强前列腺增殖过程的特性，这可能是一个不利因素。
