Kisliakova N D, Luntovskaia V A
Vopr Onkol. 1979;25(5):12-4.
To obtain more insight into the problem on the concentration of active androgens in the male organism, the diurnal elimination of testosterone, epitestosterone and estrogens in the urine of male patients with cancer of the lung, urinary bladder, larynx and prostate (321 patients), in stage II--III, was estimated. In patients with cancer of the lung and urinary bladder testosterone was found to be lowered, while total estrogens--lowered or unchanged irrespective of age, a relative hyperestrogenization being noted in them. Contrary, in cancer of the larynx and prostate the male hormones were predominating over female ones (hyperandrogenization). In all the examined patients irrespective of the tumor process localization a relative or even absolute predominance of epitestosterone over testosterone was evident.
为了更深入了解男性机体中活性雄激素的浓度问题，对处于II - III期的321例肺癌、膀胱癌、喉癌和前列腺癌男性患者尿液中睾酮、表睾酮和雌激素的日排泄量进行了评估。发现肺癌和膀胱癌患者的睾酮水平降低，而无论年龄大小，总雌激素水平降低或不变，且这些患者存在相对雌激素化现象。相反，喉癌和前列腺癌患者中男性激素占主导地位（雄激素化）。在所有接受检查的患者中，无论肿瘤发生部位如何，表睾酮相对于睾酮均明显呈现相对甚至绝对优势。
