与雄激素性脱发相关的毛囊周围体征的组织学特征。

Histological features of peripilar signs associated with androgenetic alopecia.

作者信息

Deloche Claire, de Lacharrière Olivier, Misciali Cosimo, Piraccini Bianca Maria, Vincenzi Colombina, Bastien Philippe, Tardy Isabelle, Bernard Bruno A, Tosti Antonella

机构信息

Centre Charles Zviak, L'Oréal Recherche, 90 rue du Général Roguet, 92583 Clichy Cedex, France.

出版信息

Arch Dermatol Res. 2004 Mar;295(10):422-8. doi: 10.1007/s00403-003-0447-y. Epub 2004 Jan 31.

DOI:10.1007/s00403-003-0447-y

PMID:14758487

Abstract

BACKGROUND

A study of the scalp in a large cohort of volunteers with androgenetic alopecia using macrophotographs showed the presence of peripilar signs (PPS) around the hair ostia.

OBJECTIVE

The aim of the present study was to establish the histopathological features related to PPS.

DESIGN

Prospective clinicopathological study. SETTING. Department of Dermatology, University Hospital of Bologna.

PATIENTS

A group of 40 patients (21 males and 19 females) participated in the study. Macrophotographs of the scalp were taken using a Dermaphot camera and PPS were scored using a three-point scale. Hair density and PPS were clinically scored according to reference scales. Two punch biopsies from the photographed area were obtained from each subject and histological analysis was performed on vertical and horizontal sections.

OBSERVATIONS

Clinical parameters indicated that PPS were already detectable on scalp with high hair density. Moreover, in patients with high hair density (score >4), a significant relationship was found between the PPS score and the global score for perifollicular infiltrates. Thus PPS are linked to superficial perifollicular lymphocytic infiltrates in early androgenetic alopecia.

CONCLUSIONS

PPS could be the clinical signs reflecting the presence of perifollicular infiltrates.

摘要

背景

一项针对大量雄激素性脱发志愿者头皮的研究，通过 macrophotographs 显示在毛囊口周围存在毛囊周体征（PPS）。

目的

本研究的目的是确定与 PPS 相关的组织病理学特征。

设计

前瞻性临床病理研究。地点：博洛尼亚大学医院皮肤科。

患者

一组 40 名患者（21 名男性和 19 名女性）参与了该研究。使用 Dermaphot 相机拍摄头皮的 macrophotographs，并使用三分制对 PPS 进行评分。根据参考量表对头发密度和 PPS 进行临床评分。从每个受试者的拍摄区域获取两块钻孔活检组织，并对垂直和水平切片进行组织学分析。