de Lacharrière O, Deloche C, Misciali C, Piraccini B M, Vincenzi C, Bastien P, Tardy I, Bernard B A, Tosti A
L'Oréal Research, Life Science, Prospective Clinical Research, 90 rue du Général Roguet, Clichy 92100, France.
Arch Dermatol. 2001 May;137(5):641-6.
The degree of androgenetic alopecia is generally evaluated either by global clinical scales or time-consuming methods like phototrichogram or histological studies. We describe a new clinical and reliable scoring method based on hair diameter diversity.
(1) The clinical macroscopic scoring we propose for hair density was significantly correlated with Hamilton classification and with histological hair density. (2) Diversity in hair diameter was the main and most accurate clinical parameter linked to follicle miniaturization. (C) The anagen-telogen ratio decreased in parallel with the decrease in clinical hair density score.
Considering that hair follicle miniaturization is the key point during androgenic alopecia onset and development, diversity in hair diameter represents an important feature to consider as an accurate clinical sign reflecting hair follicle miniaturization. Moreover, diversity in hair diameter seems to be an easily accessible and reliable parameter that should be taken into consideration for further characterization of hair disorders. By itself, we believe that this clinical feature constitutes a new tool of substantial help for the diagnosis and management of androgenic alopecia.
雄激素性脱发的程度通常通过整体临床量表或耗时的方法如毛发镜检或组织学研究来评估。我们描述了一种基于毛发直径差异的新型临床且可靠的评分方法。
（1）我们提出的用于评估毛发密度的临床宏观评分与汉密尔顿分级以及组织学毛发密度显著相关。（2）毛发直径的差异是与毛囊小型化相关的主要且最准确的临床参数。（3）生长期与休止期的比例随着临床毛发密度评分的降低而平行下降。
鉴于毛囊小型化是雄激素性脱发发生和发展过程中的关键点，毛发直径的差异代表了一个重要特征，可作为反映毛囊小型化的准确临床体征加以考虑。此外，毛发直径的差异似乎是一个易于获取且可靠的参数，在进一步描述毛发疾病时应予以考虑。我们认为，这一临床特征本身构成了一种对雄激素性脱发的诊断和管理有很大帮助的新工具。
