Rakhov D A, Iudanova L S, Rubin V I
Urol Nefrol (Mosk). 1992 Jul-Dec(4-6):31-3.
Mg-, Ca-, Na-, K-ATPase, acetylcholine esterase and sulfhydryl groups of red blood cell membranes were evaluated in 40 patients with chronic glomerulonephritis in preazotemia stage versus 34 healthy controls. In chronic glomerulonephritis there was a significant fall in Ca-ATPase activity irrespective of the disease pattern. Na, K-ATPase tended tot a decrease contrary to sulfhydryl groups levels and acetylcholine esterase activity. In the nephrotic variant of the disease Na, K-ATPase, Ca-ATPase activity dropped and came to increase due to glucocorticosteroid treatment. The changes are attributed to modification of the lipid bilayer of the red blood cell membranes.
对40例氮质血症前期慢性肾小球肾炎患者和34名健康对照者的红细胞膜上的镁、钙、钠、钾 - ATP酶、乙酰胆碱酯酶和巯基进行了评估。在慢性肾小球肾炎中，无论疾病类型如何，钙 - ATP酶活性均显著下降。钠钾 - ATP酶与巯基水平和乙酰胆碱酯酶活性相反，有下降趋势。在该疾病的肾病变体中，钠钾 - ATP酶、钙 - ATP酶活性下降，而糖皮质激素治疗后活性增加。这些变化归因于红细胞膜脂质双层的改变。
