Rakhov D A
Ter Arkh. 1991;63(10):147-9.
Activity of Mg-; Ca-, Na, K-ATPases of the erythrocytic membrane was studied in 67 adult patients with chronic glomerulonephritis (CGN) in the preazotemic stage and in 34 healthy persons. A significant reduction of Ca-ATPase activity was revealed, most pronounced in patients with the hypertensive and combined variants of CGN. Na, K-ATPase activity tended towards decline in all the patients. The rise of the initially decreased activity of Ca- and Na, K-ATPases was demonstrated in patients with the nephrotic variant of CGN treated with glucocorticosteroids. The decline of ATPase activity is related to the damage of cellular membranes in CGN in the preazotemic stage of the disease, which requires the carrying out of active membrane-stabilizing therapy.
对67例氮质血症前期的成年慢性肾小球肾炎（CGN）患者及34名健康人的红细胞膜镁 - 、钙 - 、钠、钾 - ATP酶活性进行了研究。结果显示钙 - ATP酶活性显著降低，在高血压型和混合型CGN患者中最为明显。所有患者的钠、钾 - ATP酶活性均有下降趋势。接受糖皮质激素治疗的肾病型CGN患者，其最初降低的钙 - 和钠、钾 - ATP酶活性有所升高。ATP酶活性的下降与疾病氮质血症前期CGN细胞膜的损伤有关，这需要进行积极的膜稳定治疗。
