Rivault Freddy, Tranoy-Opalinski Isabelle, Gesson Jean-Pierre
UMR 6514, Laboratoire de Synthèse et Réactivité des Substances Naturelles, Université de Poitiers, 40 avenue du Recteur Pineau, 86022 Poitiers, France.
Bioorg Med Chem. 2004 Feb 15;12(4):675-82. doi: 10.1016/j.bmc.2003.11.026.
The synthesis, enzymatic hydrolysis and self decomposition of model glucuronylated prodrugs, incorporating a new linker with different aryl substituents, have been studied. Determination of kinetic parameters (V(max), K(m) and t(1/2)) showed the important role of aromatic substitution in enzymatic recognition and linker decomposition.
我们研究了含有新型连接基及不同芳基取代基的模型葡糖醛酸化前药的合成、酶促水解和自分解过程。动力学参数（V(max)、K(m)和t(1/2)）的测定表明了芳基取代在酶识别和连接基分解中的重要作用。
