患有囊性纤维化的婴幼儿的气道结构异常
Structural airway abnormalities in infants and young children with cystic fibrosis.
作者信息
Long Frederick R, Williams Roger S, Castile Robert G
机构信息
Children's Radiological Institute, Children's Hospital, Department of Pediatrics, Ohio State University School of Medicine and Public Health, Children's Hospital and Children's Research Institute, Columbus, Ohio 43205-2696, USA.
出版信息
J Pediatr. 2004 Feb;144(2):154-61. doi: 10.1016/j.jpeds.2003.09.026.
OBJECTIVES
To determine whether the airway structure of infants and young children with cystic fibrosis (CF) differs from that of normal children by using high-resolution computed tomography (HRCT) imaging. Study design Full-inflation, controlled ventilation HRCT images of the lungs were obtained at four anatomic levels in 34 infants with CF (age, 2.4+/-1.4 years) and 20 control infants (age, 1.8+/-1.4 years). Short axis diameters of all clearly identifiable, round airway/vessel pairs were measured to obtain airway wall thickness (AWT), airway lumen diameter (ALD), and vessel diameter (VD).
RESULTS
In infants with CF, mean AWT (+/-SD) was 0.58+/-0.13 mm, ALD was 1.31+/-0.56 mm, and VD was 1.62+/-0.58 mm. In control infants, mean AWT was 0.49+/-0.13 mm, ALD was 1.07+/-0.42 mm, and VD was 1.86+/-0.64 mm. Mean AWT and ALD were greater in children with CF than in normal subjects (P<.001). ALD:VD ratios increased with age in patients with CF compared with control subjects (P=.026).
CONCLUSIONS
The airways of infants and young children with CF have thicker walls and are more dilated than those of normal infants.
目的
通过高分辨率计算机断层扫描（HRCT）成像，确定囊性纤维化（CF）婴幼儿的气道结构是否与正常儿童不同。研究设计 在34名CF婴幼儿（年龄2.4±1.4岁）和20名对照婴幼儿（年龄1.8±1.4岁）的四个解剖层面获取肺部全充气、控制通气的HRCT图像。测量所有清晰可辨的圆形气道/血管对的短轴直径，以获得气道壁厚度（AWT）、气道腔直径（ALD）和血管直径（VD）。
结果
CF婴幼儿的平均AWT（±标准差）为0.58±0.13mm，ALD为1.31±0.56mm，VD为1.62±0.58mm。对照婴幼儿的平均AWT为0.49±0.13mm，ALD为1.07±0.42mm，VD为1.86±0.64mm。CF患儿的平均AWT和ALD高于正常受试者（P<0.001）。与对照受试者相比，CF患者的ALD:VD比值随年龄增加（P=0.026）。
结论
CF婴幼儿的气道壁比正常婴幼儿更厚且更扩张。
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