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爱尔兰西部腹主动脉瘤破裂患者的生存率:是否存在预后指标?

Survival of ruptured abdominal aortic aneurysms in the west of Ireland: do prognostic indicators of outcome exist?

作者信息

Sultan S, Manecksha R, O'Sullivan J, Hynes N, Quill D, Courtney D

机构信息

Western Vascular Institute, Department of Vascular and Endovascular Surgery, University College Hospital, Galway, Republic of Ireland.

出版信息

Vasc Endovascular Surg. 2004 Jan-Feb;38(1):43-9. doi: 10.1177/153857440403800105.

Abstract

Ruptured abdominal aortic aneurysm (RAAA) is a demanding vascular surgical problem and the cause of significant morbidity and mortality. The aim of this study was to identify prognostic factors that influence outcome. Over 6 years, 42 ruptured abdominal aortic aneurysms were operated on with a mean diameter of 7.2 cm. RAAA was defined as free intraperitoneal rupture. Data were collected retrospectively from hospital medical records. The male: female ratio was 8:1 and the mean age was 74 years (range 55-89). Fifteen were in hypovolemic shock and 27 patients were clinically stable. The perioperative mortality rate for the 15 shocked patients was 60% (9 patients) and the 1-year cumulative survival rate was 33%. The perioperative mortality rate for the 27 clinically stable patients was 40% (11 patients) and the 1-year cumulative survival rate was 56%. Survival curves were constructed for these groups to compare male versus female, age >/= 70 versus age < 70, shocked versus stable, and preoperative hemoglobin (Hb) </= 10 vs > 10. No patient with preoperative cardiac arrest survived more than 24 hours. With VassarStats, the confidence interval for age, gender, hemodynamic status, and preoperative Hb were calculated. The standard weighted mean analysis by ANOVA gave a p value of < 0.001. The overall 30-day mortality rate was 47% (20 of 42) and the 1-year mortality rate was 52% (22 of 42). Male patients over 70 years with RAAA in hypovolemic shock with low Hb have a higher 30-day mortality rate and few survive more than 1 year. The study suggests that each of these 4 parameters separately was not a strong prognostic indicator. Collectively, however, they strongly influence the prognosis of patients with RAAA. These findings strengthen the case for selective treatment for RAAA.

摘要

腹主动脉瘤破裂(RAAA)是一个极具挑战性的血管外科问题,也是导致严重发病和死亡的原因。本研究的目的是确定影响预后的因素。在6年多的时间里,对42例破裂的腹主动脉瘤进行了手术,平均直径为7.2厘米。RAAA被定义为腹膜内自由破裂。数据从医院病历中回顾性收集。男女比例为8:1,平均年龄为74岁(范围55 - 89岁)。15例处于低血容量休克状态,27例患者临床稳定。15例休克患者的围手术期死亡率为60%(9例),1年累积生存率为33%。27例临床稳定患者的围手术期死亡率为40%(11例),1年累积生存率为56%。为这些组构建生存曲线,以比较男性与女性、年龄≥70岁与年龄<70岁、休克与稳定状态以及术前血红蛋白(Hb)≤10与>10的情况。术前心脏骤停的患者无一存活超过24小时。使用VassarStats计算年龄、性别、血流动力学状态和术前Hb的置信区间。通过方差分析的标准加权均值分析得出p值<0.001。总体30天死亡率为47%(42例中的20例),1年死亡率为52%(42例中的22例)。70岁以上患有RAAA且处于低血容量休克且Hb较低的男性患者30天死亡率较高,很少有患者存活超过1年。该研究表明,这4个参数单独来看都不是强有力的预后指标。然而,综合起来,它们强烈影响RAAA患者的预后。这些发现强化了对RAAA进行选择性治疗的理由。

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