重复蛋白的一致性设计
Consensus design of repeat proteins.
作者信息
Forrer Patrik, Binz H Kaspar, Stumpp Michael T, Plückthun Andreas
机构信息
Biochemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
出版信息
Chembiochem. 2004 Feb 6;5(2):183-9. doi: 10.1002/cbic.200300762.
PMID:14760739
Abstract
Consensus design is a valuable protein-engineering method that is based on statistical information derived from sequence alignments of homologous proteins. Recently, consensus design was adapted to repeat proteins. We discuss the potential of this novel repeat-based approach for the design of consensus repeat proteins and repeat protein libraries and summarize recent results from such experiments.
摘要
共有序列设计是一种有价值的蛋白质工程方法，它基于从同源蛋白质序列比对中获得的统计信息。最近，共有序列设计被应用于重复蛋白。我们讨论了这种基于重复序列的新方法在设计共有序列重复蛋白和重复蛋白文库方面的潜力，并总结了此类实验的最新结果。
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