Mizuguchi Shinjiro, Nishida Tatsuya, Kawata Yasuhiro, Izumi Nobuhiro, Nishiyama Noritoshi, Inoue Kiyotoshi
Department of Thoracic Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Jpn J Thorac Cardiovasc Surg. 2004 Jan;52(1):36-40. doi: 10.1007/s11748-004-0060-9.
A rare case of synchronous double lung cancers having developed from bilateral bullous disease is reported. A 51-year-old man was admitted because of severe cough. Imaging studies revealed a left apical bulla measuring 10 cm, and another bulla measuring 8 cm containing viscous fluid on the right apex. In the next year, chest computed tomography showed increased size of the mass in the right apical bulla. Upper right lobectomy and left bullectomy were performed. Histological examination of the resected specimens revealed a large cell carcinoma having developed the wall of the bulla in the right apex, and a moderately differentiated papillary adenocarcinoma having developed in the wall of the left bulla. The patient had an uneventful recovery and has been in good health without recurrence for 3 years since surgery. We emphasize the need to be aware of the potential development of lung cancer in patients with bullous disease.
报告了一例罕见的源自双侧大疱性疾病的同步双肺癌病例。一名51岁男性因严重咳嗽入院。影像学检查发现左肺尖有一个10厘米的大疱，右肺尖有另一个8厘米的大疱，内含粘性液体。次年，胸部计算机断层扫描显示右肺尖大疱内肿块增大。行右上叶切除术和左肺大疱切除术。切除标本的组织学检查显示，右肺尖大疱壁发生了大细胞癌，左肺大疱壁发生了中分化乳头状腺癌。患者术后恢复顺利，自手术以来3年一直健康无复发。我们强调需要意识到大疱性疾病患者发生肺癌的潜在可能性。
