Tamura Masaya, Ohta Yasuhiko, Tsunezuka Yoshio, Sato Hideo
Department of Thoracic Surgery, Ishikawa Prefectural Central Hospital, Ishikawa, Japan.
Jpn J Thorac Cardiovasc Surg. 2004 Jan;52(1):41-4. doi: 10.1007/s11748-004-0061-8.
We present a case of a 65-year-old woman whose thyroid cancer metastasized to the lesion of primary lung cancer. Ten years after total thyroidectomy for thyroid cancer, chest radiograph by medical check-up demonstrated three nodular lesions in the bilateral lung fields. Segmental resection of the left S6, partial resection of right S4 and left S10 were performed to remove those lesions. Histologically, small nodules in the right S4 and S10 were diagnosed as a metastatic tumor of thyroid and well differentiated adenocarcinoma, respectively. Left S6 lesion 1.5 cm in diameter was also diagnosed as well-differentiated adenocarcinoma (Noguchi type C), however, small metastatic foci of papillary adenocarcinoma was identified within the lesion which revealed to be "cancer in cancer metastasis". Metastasis of cancer to another primary cancer is a rare event. We discuss interesting phenomenon of cancer in cancer metastasis with a review of the literature.
我们报告一例65岁女性，其甲状腺癌转移至原发性肺癌病灶。在因甲状腺癌行甲状腺全切除术后十年，体检胸部X光片显示双侧肺野有三个结节性病灶。对左侧S6段进行了节段性切除，对右侧S4段和左侧S10段进行了部分切除以切除这些病灶。组织学上，右侧S4和S10的小结节分别被诊断为甲状腺转移瘤和高分化腺癌。左侧S6直径1.5 cm的病灶也被诊断为高分化腺癌（野口C型），然而，在该病灶内发现了乳头状腺癌的小转移灶，显示为“癌中之癌转移”。癌症转移至另一种原发性癌症是一种罕见事件。我们结合文献复习讨论了癌中之癌转移这一有趣现象。
