Nabili Vishad, Natarajan Sathima, Hirschovitz Sharon, Bhuta Sunita, Abemayor Elliot
Division of Head and Neck Surgery Otolaryngology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Am J Otolaryngol. 2007 May-Jun;28(3):218-20. doi: 10.1016/j.amjoto.2006.08.002.
Collision tumors are rare entities wherein 2 separate, distinct histologic malignant neoplasms occur in adjacent anatomic proximity. The 2 malignancies may originate from the same organ or occur as metastases from other sites. We present a case of a collision tumor of metastatic lung adenocarcinoma and papillary thyroid carcinoma occurring in the thyroid gland of a 63-year-old woman who presented with a multinodular central neck mass. After excision and histopathologic examination, this tumor was identified as a collision tumor. This is the first report of this unique combination of tumors occurring in the thyroid gland. This case report emphasizes the role of detailed histopathologic analysis and the use of immunohistochemistry in better identifying rare thyroid neoplasms.
碰撞瘤是罕见的实体瘤，其中两种独立、不同组织学类型的恶性肿瘤在相邻的解剖部位出现。这两种恶性肿瘤可能起源于同一器官，也可能是其他部位转移而来。我们报告一例63岁女性甲状腺内发生的转移性肺腺癌与甲状腺乳头状癌碰撞瘤病例，该患者表现为颈部中央多结节肿块。切除及组织病理学检查后，此肿瘤被确诊为碰撞瘤。这是甲状腺内出现这种独特肿瘤组合的首例报告。本病例报告强调了详细的组织病理学分析及免疫组化在更好地识别罕见甲状腺肿瘤中的作用。
