Ruocco E, Baroni A, Cutrì F Tripodi, Filioli F Grimaldi
Department of Dermatology, Second University of Naples, Naples, Italy.
J Eur Acad Dermatol Venereol. 2003 Nov;17(6):686-8. doi: 10.1046/j.1468-3083.2003.00730.x.
A case of granuloma annulare that developed in a site of healed herpes zoster is reported. Polymerase chain reaction failed to detect VZV DNA in a biopsy specimen. The occurrence of different types of cutaneous reactions in a body area previously affected by herpes virus infection is known as Wolf's isotopic response. Pathogenesis may be due to a local neuroimmune dysregulation set off by herpesvirus-induced lesions of dermal sensory nerve fibres.