Xue Qiao, Ji Jie, Fan Wen-Ge, Pan Jian-Peng, Wei Mei, Ding Hao, Zhao Jun
Department of Dermatology, Changshu No. 1 People's Hospital, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu Province, 215500, People's Republic of China.
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Oct 13;16:2869-2878. doi: 10.2147/CCID.S429143. eCollection 2023.
To understand the situation and risk factors of skin lesions following the eruption of shingles.
We selected 275 patients with shingles who had been diagnosed and treated in the Dermatology Department of Changshu No. 1 People's Hospital between July 2017 and March 2022. Age, gender, skin lesion site, skin lesion type, prodromal pain, history of diabetes, history of hypertension, history of other immune diseases, as well as other pertinent clinical data, were collected. The severity and pain of patients with severe shingles were evaluated, and their fasting blood sugar and plasma albumin were measured for routine antiviral treatment. They were followed up 6 months-the types of skin lesions and pertinent clinical data were compared, and the risk factors for skin lesions were analyzed.
There were no statistically significant differences in gender, age, or site among the different types of skin lesions (P > 0.05). The severity of skin lesions, acute pain, history of diabetes, history of scars, low immune function, combined with hypoproteinemia, squeezing and stripping behavior, and post-herpetic neuralgia (PHN) were significantly associated with skin lesions (P < 0.05). The results of multivariate analysis showed that: age ≥60 years old, severe skin injury combined with diabetes, low immune function, scar history, squeezing and stripping were independent risk factors for the development of skin lesions due to shingles.
There is no significant difference in age, gender, site, or other characteristics between the types of skin lesions due to shingles. The independent risk factors of skin lesions due to shingles are old age, severe rash, history of scars, diabetes, low immunity, squeezing, and peeling.
了解带状疱疹发疹后皮肤损害的情况及危险因素。
选取2017年7月至2022年3月在常熟市第一人民医院皮肤科确诊并治疗的275例带状疱疹患者。收集年龄、性别、皮肤损害部位、皮肤损害类型、前驱疼痛、糖尿病史、高血压史、其他免疫病史以及其他相关临床资料。对重症带状疱疹患者的病情严重程度及疼痛情况进行评估，检测空腹血糖及血浆白蛋白后进行常规抗病毒治疗。随访6个月，比较皮肤损害类型及相关临床资料，分析皮肤损害的危险因素。
不同类型皮肤损害在性别、年龄、部位方面差异无统计学意义（P＞0.05）。皮肤损害严重程度、急性疼痛、糖尿病史、瘢痕史、免疫功能低下、合并低蛋白血症、挤压搔抓行为及带状疱疹后神经痛（PHN）与皮肤损害显著相关（P＜0.05）。多因素分析结果显示：年龄≥60岁、重症皮肤损害合并糖尿病、免疫功能低下、瘢痕史、挤压搔抓是带状疱疹发生皮肤损害的独立危险因素。
带状疱疹所致皮肤损害类型在年龄、性别、部位等特征方面无显著差异。带状疱疹发生皮肤损害的独立危险因素为高龄、皮疹严重、瘢痕史、糖尿病、免疫力低下、挤压搔抓。
