Harris R, Whittemore A S, Itnyre J
Department of Health Research and Policy, Stanford University School of Medicine, CA 94305-5092.
Am J Epidemiol. 1992 Nov 15;136(10):1204-11. doi: 10.1093/oxfordjournals.aje.a116428.
Epithelial ovarian neoplasms of low malignant potential, also called borderline ovarian tumors, have various features of malignancy, but they do not invade the ovarian stroma. Women with these tumors usually are younger when diagnosed and have better prognoses than do women with invasive tumors. There have been few epidemiologic studies of borderline tumors, and it is unclear whether there are etiologic differences between the two types of tumor behavior. Combined data from nine case-control studies, conducted from 1974 to 1986 and representing 327 white women with tumors of low malignant potential and 4,144 white controls, were used to evaluate the relation between these tumors and personal characteristics related to invasive ovarian cancer. The risk profile for tumors of low malignant potential was found to be similar to that for invasive tumors, with two exceptions: Compared with that of invasive tumors, risk of borderline tumors was less clearly reduced among women who had used oral contraceptives and more clearly elevated among women with a history of infertility.
低恶性潜能的上皮性卵巢肿瘤，也称为卵巢交界性肿瘤，具有各种恶性特征，但不侵犯卵巢间质。患有这些肿瘤的女性通常在诊断时年龄较小，且预后比浸润性肿瘤患者更好。关于交界性肿瘤的流行病学研究很少，目前尚不清楚这两种肿瘤行为在病因上是否存在差异。1974年至1986年进行的9项病例对照研究的综合数据，涵盖了327名患有低恶性潜能肿瘤的白人女性和4144名白人对照，用于评估这些肿瘤与浸润性卵巢癌相关个人特征之间的关系。结果发现，低恶性潜能肿瘤的风险特征与浸润性肿瘤相似，但有两个例外：与浸润性肿瘤相比，口服避孕药的女性患交界性肿瘤的风险降低得不太明显，而有不孕史的女性患交界性肿瘤的风险升高得更明显。
