Altindis Mustafa, Arikan Yuksel, Cetinkaya Zafer, Polat Coskun, Yilmaz Sezgin, Akbulut Gökhan, Dilek Osman Nuri, Gokce Ozcan
Department of Microbiology and Clinical Microbiology, Afyon Kocatepe University, Afyon, Turkey.
J Invest Surg. 2004 Jan-Feb;17(1):41-4.
Hydatid disease is still endemic in many devoloping countries and continues to be an important cause of morbidity. The objective of this study was to determine the in vitro scolicidal effects of octenidine hydrochloride in different concentrations using different exposure times. After hydatid cyst liquid was left to precipitate for 1 h to obtain cystic sand, various concentrations of octenidine (undiluted, 1% and 0.1% diluted) were added to concentrated hydatid cyst sediments for 5, 10, 15, 20, 25, 30, 45, and 60 min, and scolicidal effects of octenidine were compared with 20% saline and control group for the same times. It was found that undiluted octenidine had a strong scolicidal effect at 15 min compared to saline at 20%. One percent octenidine had a scolicidal effect at 30 min. However, 0.1% octenidine did not have enough scolicidal effect in 1 h. It was concluded that undiluted and 1% diluted octenidine might be used for scolicidal purpose in the treatment of hydatid disease.
包虫病在许多发展中国家仍然是地方病，并且仍然是发病的一个重要原因。本研究的目的是使用不同的暴露时间来确定不同浓度的盐酸奥替尼啶的体外杀头节效果。将包虫囊肿液静置沉淀1小时以获得囊砂后，将不同浓度的奥替尼啶（未稀释、1%稀释和0.1%稀释）添加到浓缩的包虫囊肿沉淀物中5、10、15、20、25、30、45和60分钟，并在相同时间将奥替尼啶的杀头节效果与20%盐水和对照组进行比较。结果发现，与20%的盐水相比，未稀释的奥替尼啶在15分钟时具有很强的杀头节效果。1%的奥替尼啶在30分钟时具有杀头节效果。然而，0.1%的奥替尼啶在1小时内没有足够的杀头节效果。得出的结论是，未稀释和1%稀释的奥替尼啶可用于包虫病治疗中的杀头节目的。
