鼠伤寒沙门氏菌中 SopA 的 III 型依赖性分泌需要 InvB。
InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium.
作者信息
Ehrbar Kristin, Hapfelmeier Siegfried, Stecher Bärbel, Hardt Wolf-Dietrich
机构信息
Institute of Microbiology, ETH Zürich, 8092 Zürich, Switzerland.
出版信息
J Bacteriol. 2004 Feb;186(4):1215-9. doi: 10.1128/JB.186.4.1215-1219.2004.
Abstract
The Salmonella effector protein SopA is translocated into host cells via the SPI-1 type III secretion system (TTSS) and contributes to enteric disease. We found that the chaperone InvB binds to SopA and slightly stabilizes it in the bacterial cytosol and that it is required for its transport via the SPI-1 TTSS.
摘要
沙门氏菌效应蛋白SopA通过SPI-1 III型分泌系统（TTSS）转运到宿主细胞中，并导致肠道疾病。我们发现伴侣蛋白InvB与SopA结合，并在细菌胞质溶胶中使其略微稳定，且它是SopA通过SPI-1 TTSS转运所必需的。
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本文引用的文献
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