Rose M L, Semrad S D
Department of Surgical Science, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Am J Vet Res. 1992 Dec;53(12):2305-10.
The clinical efficacy of the lazaroid, tirilazad mesylate, a new therapeutic agent for prophylaxis and treatment of endotoxemia, was evaluated in 24 neonatal Holstein calves. Endotoxemia was induced by IV infusion of commercial Escherichia coli lipopolysaccharide (3.25 micrograms/kg of body weight) over 3 hours. Group-1 calves were given endotoxin alone; group-2 calves were given an infusion of 0.9% sterile saline solution, then were treated with tirilazad mesylate (1.5 mg/kg) 1 hour after the infusion was started. Group-3 calves were treated with tirilazad mesylate 1 hour after the start of the endotoxin infusion, and group-4 calves were given tirilazad mesylate 1 hour before the start of the endotoxin infusion. Clinical signs of endotoxemia were mitigated by tirilazad mesylate. In addition, tirilazad mesylate protected calves from endotoxin-induced hyperglycemia; treatment after endotoxin infusion decreased the severity of hypoglycemia and prevented lactic acidosis. Treatment with tirilazad mesylate after initiation of endotoxin infusion was as protective as was pretreatment.
在24头新生荷斯坦犊牛中评估了新型内毒素血症预防和治疗药物拉扎罗类药物甲磺司替拉扎德的临床疗效。通过在3小时内静脉输注商业大肠杆菌脂多糖（3.25微克/千克体重）诱导内毒素血症。第1组犊牛仅给予内毒素；第2组犊牛先输注0.9%无菌盐溶液，然后在输注开始1小时后用甲磺司替拉扎德（1.5毫克/千克）治疗。第3组犊牛在内毒素输注开始1小时后用甲磺司替拉扎德治疗，第4组犊牛在内毒素输注开始前1小时给予甲磺司替拉扎德。甲磺司替拉扎德减轻了内毒素血症的临床症状。此外，甲磺司替拉扎德保护犊牛免受内毒素诱导的高血糖影响；内毒素输注后治疗降低了低血糖的严重程度并预防了乳酸酸中毒。内毒素输注开始后用甲磺司替拉扎德治疗与预处理一样具有保护作用。
