Semrad S D, Dubielzig R
Department of Medical and Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Can J Vet Res. 1994 Jan;58(1):67-70.
Tirilazad mesylate (TM:U74006F), a nonglucocorticoid 21-aminosteroid (lazaroid), is beneficial in the treatment of experimentally-induced ischemic injury following brain and spinal cord trauma, subarachnoid hemorrhage, hypovolemic shock and endotoxemia. This study investigated the effects of TM following repeated administration in sixteen healthy and endotoxemic calves. Group A calves received TM 3 mg/kg IV; group B calves received Escherichia coli endotoxin in increasing doses (0.1 to 20 micrograms/kg IV); group C calves received TM and endotoxin and group D calves received sterile saline (10 mL). Endotoxin, TM and saline were given every eight hours for five days. Mild, transient tachypnea was observed following TM administration. The drug suppressed clinical signs of endotoxemia until larger doses of endotoxin were given. At necropsy no substantial lesions were observed in groups A and D. Groups B and C had lesions consistent with endotoxemia but only group C calves had evidence of abomasal and ruminal ulceration. Although TM may be of benefit in the treatment of endotoxemia, further studies are needed to determine the optimal dosage and potential side effects in the endotoxic bovine neonate.
甲磺替拉扎德（TM：U74006F），一种非糖皮质激素类21-氨基类固醇（拉扎罗类药物），在治疗实验性诱导的脑和脊髓创伤、蛛网膜下腔出血、低血容量性休克及内毒素血症后的缺血性损伤方面具有益处。本研究调查了在16头健康及内毒素血症犊牛中重复给药后TM的作用。A组犊牛静脉注射TM 3mg/kg；B组犊牛静脉注射递增剂量（0.1至20微克/千克）的大肠杆菌内毒素；C组犊牛接受TM和内毒素，D组犊牛接受无菌生理盐水（10毫升）。内毒素、TM和生理盐水每8小时给药一次，持续5天。注射TM后观察到轻度、短暂的呼吸急促。该药物可抑制内毒素血症的临床症状，直至给予更大剂量的内毒素。尸检时，A组和D组未观察到实质性病变。B组和C组有与内毒素血症相符的病变，但只有C组犊牛有皱胃和瘤胃溃疡的证据。尽管TM可能对内毒素血症的治疗有益，但仍需要进一步研究以确定内毒素血症新生犊牛的最佳剂量和潜在副作用。
