Golden Sherita Hill, Chong Rachel
Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, 2024 E. Monument Street, Suite 2-600, Baltimore, MD 21205, USA.
Curr Diab Rep. 2004 Feb;4(1):26-30. doi: 10.1007/s11892-004-0007-7.
Cardiovascular disease is often present in patients with newly diagnosed type 2 diabetes. It is hypothesized that both type 2 diabetes and cardiovascular disease arise from an underlying insulin resistance syndrome, including impaired glucose tolerance, hypertension, dyslipidemia, and abdominal obesity. We reviewed the literature using various epidemiologic techniques to evaluate the relation between the insulin resistance syndrome components and incident cardiovascular disease. We found that although insulin resistance is likely important in the development of cardiovascular disease seen in diabetes, lipid and blood pressure abnormalities associated with the syndrome appear to be equally important. Future studies are needed to determine the most effective treatment strategies for preventing cardiovascular disease associated with the insulin resistance syndrome and type 2 diabetes.
心血管疾病常出现在新诊断的2型糖尿病患者中。据推测，2型糖尿病和心血管疾病均源于潜在的胰岛素抵抗综合征，包括糖耐量受损、高血压、血脂异常和腹型肥胖。我们运用各种流行病学技术回顾文献，以评估胰岛素抵抗综合征各组分与心血管疾病发病之间的关系。我们发现，尽管胰岛素抵抗在糖尿病患者心血管疾病的发生中可能起重要作用，但与该综合征相关的脂质和血压异常似乎同样重要。需要开展进一步研究，以确定预防与胰岛素抵抗综合征及2型糖尿病相关的心血管疾病的最有效治疗策略。
