Pasterkamp Gerard, Galis Zorina S, de Kleijn Dominique P V
Heart Lung Institute, Laboratory of Experimental Cardiology, Utrecht University Hospital, Utrecht, The Netherlands.
Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):650-7. doi: 10.1161/01.ATV.0000120376.09047.fe. Epub 2004 Feb 5.
The artery is a dynamic organ capable of changing its geometry in response to atherosclerotic plaque formation. Expansion of the vessel diameter retards luminal narrowing and is considered a compensatory response. However, the expansive remodeling response is a "wolf in sheep's clothes," because expansion is associated with the presence of inflammatory cells, proteolysis, and a thrombotic plaque phenotype. The prevalence and clinical presentation of expansively remodeled lesions may differ among vascular beds. However, it is evident that all types of atherosclerotic arterial expansive lesions share the presence of inflammatory cells and subsequent protease activities. The potential role of inflammation and protease activity in the development of the different remodeling modes is discussed.
动脉是一个动态器官，能够根据动脉粥样硬化斑块的形成改变其几何形状。血管直径的扩张可延缓管腔狭窄，被认为是一种代偿反应。然而，扩张性重塑反应是“披着羊皮的狼”，因为扩张与炎症细胞的存在、蛋白水解和血栓形成性斑块表型有关。扩张性重塑病变的患病率和临床表现可能因血管床而异。然而，显然所有类型的动脉粥样硬化性动脉扩张性病变都存在炎症细胞和随后的蛋白酶活性。本文讨论了炎症和蛋白酶活性在不同重塑模式发展中的潜在作用。
