Gallot D, Boiret N, Vanlieferinghen P, Laurichesse H, Micorek J C, Berger M, Lemery D
Unité de Médecine Materno-Foetale, Maternité de l'Hôtel-Dieu, Clermont-Ferrand, France.
Fetal Diagn Ther. 2004 Mar-Apr;19(2):170-3. doi: 10.1159/000075144.
We report a case of an extremely severe Rhesus allo-immunization treated very early in pregnancy 12 years ago.
After chorionic villus sampling at 12 weeks for fetal blood phenotyping, two intraperitoneal transfusions at 14 and 15 weeks were given followed by two intravascular and seven exchange transfusions. A girl weighing 2,940 g was delivered vaginally at term after external cephalic version for breech presentation. To date her neurological and social development is normal.
Since the success of haematopoietic stem cell transplantations for the treatment of congenital haematologic diseases could imply early and repetitive procedures, this observation enlightens the technical feasibility of such an invasive approach and its relative safety for subsequent development.
我们报告12年前1例在妊娠极早期接受治疗的极为严重的恒河猴同种免疫病例。
在孕12周进行绒毛取样以检测胎儿血型后，于孕14周和15周进行了两次腹腔输血，随后进行了两次血管内输血和七次换血输血。一名体重2940克的女婴因臀位经外倒转术后足月顺产。迄今为止，她的神经和社交发育正常。
由于造血干细胞移植治疗先天性血液系统疾病的成功可能意味着需要早期且重复进行相关操作，该病例表明了这种侵入性方法的技术可行性及其对后续发育的相对安全性。
