De Boer Inge P, Zeestraten Eliane C M, Lopriore Enrico, van Kamp Inge L, Kanhai Humphrey H H, Walther Frans J
Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Am J Obstet Gynecol. 2008 Jan;198(1):54.e1-4. doi: 10.1016/j.ajog.2007.05.030.
To study the short-term morbidity in Rhesus hemolytic disease of infants treated either with or without intrauterine transfusions (IUT).
All term and near term infants (gestational age > or = 36 weeks) with neonatal Rhesus hemolytic disease admitted to our center between January 2000-March 2005 were retrospectively included in the study. We recorded the duration of phototherapy, the need of exchange transfusions, and the need of top-up red blood cell transfusions until 6 months of age.
A total of 89 infants were included, of whom 52 received at least one IUT. Duration of phototherapy in the IUT and no-IUT group was 3.8 and 5.1 days, respectively (P = .01). The percentage of infants requiring an exchange transfusion in the IUT group was 71% compared to 65% in the no-IUT group (P = .64). The percentage of infants requiring a top-up transfusion in the IUT and no-IUT group was 77% and 26.5%, respectively (P < .01).
Infants with Rhesus hemolytic disease treated with IUT required less days of phototherapy and more top-up red blood cell transfusions than neonates without IUT. However, the need for exchange transfusion was similar in both groups.
研究接受或未接受宫内输血（IUT）治疗的婴儿恒河猴溶血病的短期发病率。
回顾性纳入2000年1月至2005年3月间入住本中心的所有足月和近足月（胎龄≥36周）新生儿恒河猴溶血病婴儿。我们记录了光疗时间、换血需求以及直至6个月龄时补充红细胞输血的需求。
共纳入89例婴儿，其中52例接受了至少一次宫内输血。宫内输血组和未接受宫内输血组的光疗时间分别为3.8天和5.1天（P = 0.01）。宫内输血组需要换血的婴儿百分比为71%，未接受宫内输血组为65%（P = 0.64）。宫内输血组和未接受宫内输血组需要补充输血的婴儿百分比分别为77%和26.5%（P < 0.01）。
与未接受宫内输血的新生儿相比，接受宫内输血治疗的恒河猴溶血病婴儿光疗天数更少，但补充红细胞输血更多。然而，两组的换血需求相似。
