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A mild and efficient procedure for alpha-bromination of ketones using N-bromosuccinimide catalysed by ammonium acetate.

作者信息

Tanemura Kiyoshi, Suzuki Tsuneo, Nishida Yoko, Satsumabayashi Koko, Horaguchi Takaaki

机构信息

School of Dentistry at Niigata, The Nippon Dental University, Hamaura-cho, Niigata 951-8580, Japan.

出版信息

Chem Commun (Camb). 2004 Feb 21(4):470-1. doi: 10.1039/b315340a. Epub 2004 Jan 28.

DOI:10.1039/b315340a
PMID:14765263
Abstract

Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH(4)OAc in Et(2)O at 25 degrees C to give the corresponding alpha-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl(4) at 80 degrees C.

摘要

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