Zhang Xiaoke, Wang Haibo, Li Ziwei, Shu Yan, Gan Song, Zhang Xuefang, Shao Huawu, Wang Chaoyong
Central Laboratory, Chongqing University FuLing Hospital, Chongqing 408000, P.R. China.
Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
ACS Omega. 2022 Nov 1;7(45):40963-40972. doi: 10.1021/acsomega.2c04127. eCollection 2022 Nov 15.
An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions.
已建立了原位生成的偶氮烯烃中间体与α-溴代羰基化合物之间高效的[4 + 1]环化反应。在温和条件下，以高达89%的产率得到了一系列具有功能化季碳中心、骨架多样的氮杂环化合物。
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