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通过氮杂烯烃与α-溴代羰基化合物之间的[4 + 1]环化反应实现具有季碳中心的氮杂环的化学发散合成。

Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds.

作者信息

Zhang Xiaoke, Wang Haibo, Li Ziwei, Shu Yan, Gan Song, Zhang Xuefang, Shao Huawu, Wang Chaoyong

机构信息

Central Laboratory, Chongqing University FuLing Hospital, Chongqing 408000, P.R. China.

Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.

出版信息

ACS Omega. 2022 Nov 1;7(45):40963-40972. doi: 10.1021/acsomega.2c04127. eCollection 2022 Nov 15.

DOI:10.1021/acsomega.2c04127
PMID:36406503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9670695/
Abstract

An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions.

摘要

已建立了原位生成的偶氮烯烃中间体与α-溴代羰基化合物之间高效的[4 + 1]环化反应。在温和条件下，以高达89%的产率得到了一系列具有功能化季碳中心、骨架多样的氮杂环化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/dec40262c47e/ao2c04127_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/7b3b6b86d41f/ao2c04127_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/4e3629707aea/ao2c04127_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/ff39384ff69b/ao2c04127_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/dec40262c47e/ao2c04127_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/7b3b6b86d41f/ao2c04127_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/4e3629707aea/ao2c04127_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/ff39384ff69b/ao2c04127_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af93/9670695/dec40262c47e/ao2c04127_0004.jpg

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