毛大戟中的毛大戟烷二萜类化合物，对小鼠淋巴瘤细胞具有多药耐药逆转活性。

Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells.

作者信息

Valente Cláudia, Ferreira Maria José, Abreu Pedro M, Gyémánt Nora, Ugocsai Katalin, Hohmann Judit, Molnár Joseph

机构信息

Centro de Estudos de Ciências Farmacêuticas, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal.

出版信息

Planta Med. 2004 Jan;70(1):81-4. doi: 10.1055/s-2004-815464.

DOI:10.1055/s-2004-815464

PMID:14765302

Abstract

The macrocyclic jatrophane diterpene polyesters, pubescenes A - D ( 1 - 4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D ( 4) is a new compound, whose structure was established as 3beta,9alpha,-diacetoxy-7beta-benzoyloxy-15beta-hydroxy-14-oxo-2beta H-jatropha-5 E,12 E-diene by spectroscopic methods, including (1)H- (1)H COSY, HMQC, HMBC and NOESY.

摘要

从毛大戟全株干燥植物中分离得到大环麻风树烷二萜聚酯类化合物毛大戟素A - D（1 - 4），并对其在小鼠淋巴瘤细胞上的多药耐药（MDR）逆转活性进行了评估。与阳性对照维拉帕米相比，所有化合物均表现出很强的活性。毛大戟素D（4）是一种新化合物，通过（1）H-（1）H COSY、HMQC、HMBC和NOESY等光谱方法确定其结构为3β,9α-二乙酰氧基-7β-苯甲酰氧基-15β-羟基-14-氧代-2βH-麻风树-5E,12E-二烯。