从大戟属植物中分离得到的具有生物活性的 Jatrophane 二萜。
Bioactive jatrophane diterpenes from Euphorbia guyoniana.
机构信息
Chemistry of Medicinal Plants Department, National Research Center, Dokki, Cairo, Egypt.
出版信息
Phytochemistry. 2010 Feb;71(2-3):249-53. doi: 10.1016/j.phytochem.2009.10.003. Epub 2009 Nov 10.
Chromatographic investigation of the methylenechloride/methanol extract of the aerial parts of Euphorbia guyoniana afforded two jatrophane diterpenes, designated guyonianins E and F, in addition to a known jatrophane diterpene. The structures of the compounds were determined by comprehensive NMR analyses, including DEPT, COSY, HMQC, HMBC, NOESY and HRMS. These compounds exhibited cytotoxicity against human embryonic kidney 293 (HEK293) cells with IC(50) values of 35-100 microM.
色谱分析研究大戟属植物guyoniana 的地上部分的二氯甲烷/甲醇提取物，得到了两种命名为guyonianins E 和 F 的吉烷二萜，此外还有一种已知的吉烷二萜。通过全面的 NMR 分析，包括 DEPT、COSY、HMQC、HMBC、NOESY 和 HRMS，确定了这些化合物的结构。这些化合物对人胚肾 293（HEK293）细胞具有细胞毒性，IC（50）值为 35-100μM。
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